张高小

博士/高级实验师/硕士生导师

通讯地址:                 暨南大学药学院,广州市黄埔大道西601号,邮编:510632
E-mail:                   
zhanggaoxiao2005@163.com

教育经历:                                                
2000 - 2005                学士(临床医学),山西医科大学
2005 - 2008                硕士(药理学),哈尔滨医科大学
2012 - 2015                博士(药理学),暨南大学药学院
 
工作经历:     
2008 - 至今                暨南大学药学院新药研究所,高级实验师, 硕士研究生导师
 
研究方向:
神经系统疾病研究药物开发及作用机理研究
 
研究成果:
近年来,作为课题负责人或主要研究人员先后承担国家自然科学基金、“十一五”、“十二五”和“十三五”国家科技重大专项候选药物和临床前研究项目等10余项,负责或参与1项脑卒中药物开发项目、1项血管性痴呆药物开发项目、1项青光眼药物开发项目以及其它神经系统疾病的药效学评价和作用机理研究工作。其中1项脑卒中药物已经获得NMPA《药物临床试验批件》,其余项目也均在临床前研究阶段或IND阶段。现已发表论文30余篇,申请药物授权发明专利8项。

 
 

发表的部分论文 (English)

1. Zhang G, Zhang T, Wu L, et al. Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy. Neuromolecular Med. 2018, 6. 20:97-111.

2. Zhang G#, Zhang T, Li N, et al. Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post-ischaemic neuroregeneration and recovery of neurological functions in rats. Br J Pharmacol. 2018, 175(3):517-531.

3.  Zhang G, Zhang F, Zhang T, et al. Tetramethylpyrazine Nitrone Improves Neurobehavioral Functions and Confers Neuroprotection on Rats with Traumatic Brain Injury. Neurochem Res. 2016, 41(11): 2948-2957.

4. Zhang Z, Zhang G#, Sun Y, et al. Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy. Sci Rep. 2016, 6: 37148.

5. Qu Y, Zhang G#, Zhou Q, et al. Protective effect of TBN, a free radical scavenger,against excessive light-induced retinal damage in vivo and vitro. Int J Clin Exp Med. 2016, 9(7): 14968-14979.

6. Li N, Song X, Wu L, Zhang T, Zhao C, Yang X, Shan L, Yu P, Sun Y, Wang Y, Zhang G, Zhang Z. Miconazole stimulates post-ischemic neurogenesis and promotes functional restoration in rats. Neuroscience letters. 2018, 687:94-98.

7. Zhang T, Gu J, Wu L, Li N, Sun Y, Yu P, Wang Y, Zhang G, Zhang Z. Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic cerebral hypoperfusion rats and primary hippocampal neurons exposed to hypoxia. Neuropharmacology. 2017, 15(118): 137-147.

8. Zhang X, Hu H, Luo J, Deng H, Yu P, Zhang Z, Zhang G, Shan L, Wang Y. A Novel Danshensu-Tetramethylpyrazine Conjugate DT-010 Provides Cardioprotection through the PGC-1α/Nrf2/HO-1 Pathway. Biological & pharmaceutical bulletin. 2017, 40(9): 1490-1498.

9. Wu L, Cao J, Li N, Chen H, Liu W, Zhang G, Liu Y, Wang Y, Sun Y, Zhang Z. Novel neuroprotective tetramethylpyrazine analog T-006 promotes neurogenesis and neurological restoration in a rat model of stroke. Neuroreport. 2019 Apr 8. doi: 10.1097/WNR.0000000000001256.

10. Jiang J, Jian Q, Jing M, Zhang Z, Zhang G, Shan L, Yu P, Wang Y, Xu L. The novel N-methyl-d-aspartate receptor antagonist MN-08 ameliorates lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol. 2019, 66:109-118.

11. Chen H, Cao J, Zhu Z, Zhang G, Shan L, Yu P, Wang Y, Sun Y, Zhang Z. A Novel Tetramethylpyrazine Derivative Protects Against Glutamate-Induced Cytotoxicity Through PGC1α/Nrf2 and PI3K/Akt Signaling Pathways. Front Neurosci. 2018, 15;12:567.

12. Xu B, Deng H, Zhang X, Luo J, Zhang G, Zhang Z, Wang Y, Shan L. A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs. Eur J Pharmacol. 2018, 818:158-166.

13. Wang Y, Zhang X, Xu C, Zhang G, Zhang Z, Yu P, Shan L, Sun Y, Wang Y. Synthesis and Biological Evaluation of Danshensu and Tetramethylpyrazine Conjugates as Cardioprotective Agents. Chem Pharm Bull (Tokyo). 2017, 65(4):381-388.

14. Liu Z, Cai W, Lang M, Yan R, Li Z, Zhang G, Yu P, Wang Y, Sun Y, Zhang Z. Neuroprotective Effects and Mechanisms of Action of Multifunctional Agents Targeting Free Radicals, Monoamine Oxidase B and Cholinesterase in Parkinson's Disease Model. J Mol Neurosci. 2017, 61(4):498-510.

15. Liu Z, Yang S, Jin X, Zhang G, Guo B, Chen H, Yu P, Sun Y, Zhang Z, Wang Y. Synthesis and biological evaluation of memantine nitrates as a potential treatment for neurodegenerative diseases. Medchemcomm. 2016, 8(1):135-147.

16. Chen H, Tan G, Cao J, Zhang G, Yi P, Yu P, Sun Y, Zhang Z, Wang Y. Design, Synthesis, and Biological Evaluation of Novel Tetramethylpyrazine Derivatives as Potential Neuroprotective Agents. Chem Pharm Bull (Tokyo). 2017, 65(1):56-65.

17. Xu D, Chen H, Mak S, Hu S, Tsim KWK, Hu Y, Sun Y, Zhang G, Wang Y, Zhang Z, Han Y. Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models. Neurochem Int. 2016 , 99:194-205.

18. Yang Y, Yan H, Jing M, Zhang Z, Zhang G, Sun Y, Shan L, Yu P, Wang Y, Xu L. Andrographolide derivative AL-1 ameliorates TNBS-induced colitis in mice: involvement of NF-кB and PPAR-γ signaling pathways. Sci Rep. 2016, 20; 6: 29716.

19. Zhou X, Zhu L, Wang L, Guo B, Zhang G, Sun Y, Zhang Z, Lee SM, Yu P, Wang Y. Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury. Oxid Med Cell Longev. 2015, 2015: 606981.

20. Yan H, Li Y, Yang Y, Zhang Z, Zhang G, Sun Y, Yu P, Wang Y, Xu L. Protective effects of andrographolide derivative AL-1 on high glucose-induced oxidative stress in RIN-m cells. Curr Pharm Des. 2016, 22(4): 499-505.

21. Li Y, Yan H, Zhang Z, Zhang G, Sun Y, Yu P, Wang Y, Xu L. Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signalling pathway. Br J Pharmacol. 2015, 172(12): 3151-8.

22. Liang Z, Du E, Xu L, Sun Y, Zhang G, Yu P, Wang Y. Synthesis and preliminary biologic activity evaluation of nitric oxide-releasing andrographolide derivatives in RIN-m cells. Chem Pharm Bull (Tokyo). 2014, 62(6): 519-23.

23. Cui Q, Chen Y, Zhang M, Shan L, Sun Y, Yu P, Zhang G, Wang D, Zhao Z, Xu Q, Xu B, Wang Y. Design, synthesis, and preliminary cardioprotective effect evaluation of danshensu derivatives. Chem Biol Drug Des. 2014 , 84(3):282-91.

24. Yu P, Xia L, Zhao J, Zhang G, Zhang Z, Lang M, Wang Y. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs. Biol Pharm Bull. 2012, 35(8):1295-9.

25. Sun Y, Zhang G, Zhang Z, Yu P, Zhong H, Du J, Wang Y. Novel multi-functional nitrones for treatment of ischemic stroke. Bioorg Med Chem. 2012, 15;20(12):3939-45.

26. Sun Y, Yu P, Zhang G, Wang L, Zhong H, Zhai Z, Wang L, Wang Y. Therapeutic effects of tetramethylpyrazine nitrone in rat ischemic stroke models. J Neurosci Res. 2012, 90(8):1662-9.

27. Lu X, Wan S, Jiang J, Jiang X, Yang W, Yu P, Xu L, Zhang Z, Zhang G, Shan L, Wang Y. Synthesis and biological evaluations of novel apocynin analogues. Eur J Med Chem. 2011, 46(7):2691-8.

28. Sun H, Xu L, Yu P, Jiang J, Zhang G, Wang Y. Synthesis and preliminary evaluation of neuroprotection of celastrol analogues in PC12 cells. Bioorg Med Chem Lett. 2010, 20(13):3844-7.

29. Wang Z, Yu P, Zhang G, Xu L, Wang D, Wang L, Zeng X, Wang Y. Design, synthesis and antibacterial activity of novel andrographolide derivatives. Bioorg Med Chem. 2010, 18(12):4269-74.

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