王玉强

博士/教授/博士生导师/所长

通讯地址:            暨南大学药学院,广州市黄埔大道西601号,邮编:510632
E-mail:                  yuqiangwang2001@yahoo.com

教育经历:                                                                              
1983 - 1987           博士 (药物化学),美国德克萨斯大学休斯顿生物医学中心 (Univ. of Texas);
                              德克萨斯大学安德逊肿瘤中心 (M. D. Anderson Cancer Center)
1987 - 1989           博士后,美国耶鲁大学医学院药理系 (Yale University)
1990 - 1993           博士后,加拿大阿尔伯特大学化学系 (Univ. of Alberta)
 
工作经历及职称:    
2011 - 至今           暨南大学, 教授, 暨南大学新药研究所所长
2005 - 2011           暨南大学, 教授, 药学院院长, 暨南大学新药研究所所长
 
研究方向:               
新靶点药物及和中药有效成分的化学结构修饰,药理活性及作用机理研究
 
研究成果:             
从事药物化学研究20多年,在天然抗癌产物CC-1065的化学结构修饰方面的研究处于世界前沿地位。首次在美国GMP合成抗老年痴呆药物memantine,作为核心成员,其团队在美国成功将memantine开发上市。Memantine 2003年在欧美上市,2014年的销售额已达20亿美元, 正式加入“重磅炸弹”级药物的行列。作为项目负责人获得1类化学新药“硝酮嗪治疗脑中风和糖尿病肾病”和“MN-08治疗肺动脉高压”项目的临床研究批件3 项,其中硝酮嗪治疗脑中风和治疗糖尿病肾病项目目前已经进入II期临床研究,硝酮嗪治疗肌萎缩侧索硬化症项目即将开展II期临床研究,MN-08治疗肺动脉高压项目正在开展I期临床研究。先后在国内外著名学术刊物上发表论文超100余篇,申请获授权的发明专利超50余项。曾主持过美国NIH项目及中国国家重大专项、国家基金重点项目、省、市各位研究项目超30余项。

荣誉与奖励:           
获得国家重大人才工程专家 (2011年)。
 

发表论文 (English)

 

1. Farquhar, D.; Wang, Y. Novel antitumor organophosphates. The Cancer Bulletin Vol. 37, No.4. 167, 1985.

2. Beran, M.; Andersson, B. S.; Wang, Y.; McCredie, K. B.; Farquhar, D. The effects of acetalaldophosphamide, a novel stable aldophosphamide analogue, on normal human and leukemic progenitor cells in vitro: Implications for use in bone marrow purging. Cancer Res. 48, 339, 1988.

3. Andersson, B. S.; Wang, Y.; Farquhar, D. Stable in vitro active aldophosphamide acetals for bone marrow purging.  Autologous Bone Marrow Transplantation, in proceedings of the fourth international symposium. 1989.

4. Andersson, B. S.; Wang, Y.; McCredie, K. B.; Farquhar, D. Suitability of a new stable acetal analogue of aldoifosphamide for purging leukemic cells from human bone marrow. Leukemia 6, 435, 1990.

5. Wang, Y.; Farquhar, D. Aldophosphamide acetal diacetate and structural analogues: synthesis and cytotoxicity studies.  J. Med. Chem. 34, 197, 1991.

6. Wang, Y.; Liu, M. C.; Lin, T. S.; Sartorelli, A. C. Synthesis and biological evaluation of novel antitumor 3- and 5-hydroxy-4-methyl-2-formylpyridine thiosemicarbazones and their iron-chelates. J. Med. Chem. 35, 3667, 1992.

7. Wang, Y.; Lown, J. L. An alternative method for synthesis of the CC-1065 pharmacophore, 1,2,7,7a-tetrahydrocyclopropa[1,2-c]indol-4-one (CI). Heterocycles 36, 1399, 1993.

8. Wang, Y.; Gupta, R.; Huang, L.; Lown, J. W.  Synthesis and antitumor activity of CC-1065 functional analogues possessing different electron-withdrawing substituents and leaving groups. J. Med. Chem. 36, 4172, 1993.

9. Wang, Y.; Huang, L.; Wright, S. C.; Larrick, J. W. Synthesis and antitumor activity studies of doxorubicin and DNA-minor groove binding oligopeptide conjugates. Gene 149, 63, 1994.

10. Fregeau, N. L.; Wang, Y.; Pon, R, T.; Wylie, W. A.; Lown, J. W. Characterization of a CPI-Lexitropsin Conjugate: Oligonucleotide covalent complex by 1H NMR and restrained molecular dynamics simulation. J. Amer. Chem. Soc. 117, 8917, 1995.

11. Wang, Y.; Gupta, R.; Huang, L.; Luo, W.; Lown, J. W. Design, synthesis, cytotoxic properties and preliminary DNA sequencing evaluation of CPI-N-methylpyrrole hybrids. Enhancing effect of a trans double bond linker and role of the terminal amide functionality on cytotoxic potency. Anti-Cancer Drug Design 11, 15, 1996.

12. Wright, S. C.; Schellenberger, U.; Wang, H.; Wang, Y.; Kinder, D. H. Chemotherapeutic drug activation of the AP24 protease in apoptosis: Requirement for caspase 3-like proteases. Biochem. Biophys. Res. Commun. 245, 797, 1998.

13. Wang, Y.; Yuan, H.; Ye, W.; Wang, H.; Wright, S. C.; Larrick, J. W. Synthesis and preliminary biological evaluations of CC-1065 analogs: effects of different linkers and terminal amides on biological activity. J. Med. Chem. 43, 1541. 2000.

14. Wang, Y.; Yuan, H.; Wright, S. C.; Wang, H.; Larrick, J. W. Synthesis and preliminary cytotoxicity study of a cephalosporin-CC-1065 analogue. BMC Chemical Biology 1, 4, 2001.

15. Wang, Y.; Yuan, H.; Wright, S. C.; Wang, H.; Larrick, J. W. Synthesis and cytotoxicity of a biotinylated CC-1065 analogue. BMC Chemical Biology 2, 1. 2002.

16. Wang, Y.; Wright, S. C.; Larrick, J. W. Synthesis and cytotoxicity of nitrogen mustard derivatives of distamycin A. Bioorg. Med. Chem. Lett. 13, 461, 2003.

17. Wang, Y.; Ye, W.; Li, L.; Tian, Z.; Jiang, W.; Wang, H.; Wright, S. C.; Larrick, J. W. CC-1065 analogues bearing different DNA-binding subunits: synthesis, antitumor activity and preliminary toxicity study. J. Med. Chem. 46, 634, 2003.

18. Wang, Y.; Yuan, H.; Wang, H.; Wright, S. C.; Larrick, J. W. Synthesis and preliminary cytotoxicity study of glucuronide derivatives of CC-1065 analogues. Bioorg. Med. Chem. 11, 1569, 2003.

19. Wang, X.; Wang, Y.; Zheng, C. Isolation and purification of honokiol and magnolol from Cortex Magnoliae Officinalis by high-speed counter-current chromatography. J. Chromatography A., 1036, 171, 2004.

20. Wang, X.; Wang, Y.; Yuan, J.; Sun, Q.; Liu, J.; Zheng, C. An efficient new method for extraction, separation and purification of psoralen and isopsoralen from Fructus Psoraleae by supercritical fluid extraction and high-speed counter-current chromatography. J. Chromatography A, 1055, 135, 2004.

21. Wang, Y.; Li, L.; Jiang, W.; Larrick, J. W. Synthesis and evaluation of a DHA and 10-hydroxcamptothecin conjugate. Bioorg. Med. Chem. 13, 5592–5599, 2005.

22. Wang, Y.; Li, L.; Jiang, W.; Yang, Z.; Zhang, Z. Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate. Bioorg. Med. Chem. Lett. 16, 2974–2977,2006.

23. Wang, Y.; Li, L.; Tian, Z.; Jiang, W.; Larrick, J. W. Synthesis and antitumor activity of CBI-bearing ester and carbamate prodrugs of CC-1065 analogue. Bioorg. Med. Chem. 14, 7854–7861, 2006.

24. Wang, Y.; Eu, J.; Washburn, M.; Gong, T.; Chen, H. S. V.; Larrick, J. W.; Lipton, S. A.; Stamler, J, S.; Went, G. T.; Porter, S. The Pharmacology of Aminoadamantane nitrates. Curr. Alzheimer Res. 3, 201–204, 2006.

25. Wang, Y., Yang, Z.; Wright, S. C.; Larrick, J. W. Synthesis and preliminary antitumor activity of distamycin nitrogen mustards. Lett. Drug Design and Discov. 4, 37–39, 2007.

26. Suo, X. B.; Zhang, H.; Wang, Y. HPLC determination of andrographolide in rat whole blood: study on the pharmacokinetics of andrographolide incorporated in liposomes and tablets.
Biomed Chromatogr. 21, 730–734, 2007.

27. Suo, X. B.; Deng, Y. J.; Zhang, H.; Wang, Y. Degradation kinetics of water-insoluble lauroyl-indapamide in aqueous solutions: prediction of the stabilities of the drug in liposomes. Arch Pharm Res. 30, 876–883, 2007.

28. Wang, Y.; Jiang, J.; Jiang, X.; Cai, S.; Han, H.; Li, L.; Tian, T.; Jiang, W.; Zhang, Z.; Xiao, Y.; Wei Wright, S. C.; Larrick, J. W. Synthesis and antitumor activity evaluations of albumin-binding prodrugs of CC-1065 analogue. Bioorg. Med. Chem. 16, 6552–6559, 2008.

29. Sun, Y.; Jiang, J.; Zhang, Z.; Yu, P.; Wang, L.; Xu, C.; Liu, W.; Wang, Y. Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke. Bioorg. Med. Chem. 16, 8868–8874, 2008.

30. Chen, W-M.; Cheng, C.; Li, B-Z.; Ho, T-L.; Cai, Z-S.; Wang, Y.; Sun, P-H. Pyridine-4-thiol and amphoteric analogs: novel Pprotection of aryl bromides in strong alkali. Helvetica Chimica Acta91, 2062–2068, 2008.

31. Guo, J-L.; Li, B-Z.; Chen, W-M.; Sun, P-H.; Wang, Y. Synthesis of substituted 1H-pyrrol-2(5H)-ones and 2(5H)-furanones as inhibitors of P. aeruginosa biofilm. Lett. Drug Design and Discov. 6, 107–113, 2009.

32. Jiang, X.;  Yu, P.; Jiang, J.;  Zhang, Z.; Wang, Z.; Yang, Z.; Tian, Z.; Wright, S. C.; Larrick, J. W.; Wang, Y. Synthesis and evaluation of antibacterial activities of andrographolide analogues. Eur. J. Med. Chem. 44, 2936–2943, 2009.

33. Chen, J-X.; Xue, H-J.; Ye, W-C.; Fang, B-H., Liu, Y-H., Yuan, S-H., Yu, P.; Wang, Y. Activity of andrographolide and its derivatives against influenza virus in vivo and in vitro. Biol. Pharm. Bull. 32, 1385–1391, 2009.

34. Zhang, Z.; Jiang, J.; Pei, Y.; Zeng, X.; Wang, Z.; Larrick, J. W.; Wang, Y. Hypoglycemic and beta cell protective andrographolide analogue for diabetes treatment. J. Translational Med. 7:62, 2009.

35. Xu, J.; Huang, S.; Luo, H.;  Li, G.; Bao, J.; Cai, S.; Wang, Y. QSAR studies on andrographolide derivatives as α-glucosidase inhibitors. Int. J. Mol. Sci. 11, 880–895, 2010.

36. Wang, Z.; Yu, P.; Zhang, G.; Xu, L.; Wang, D.; Wang, L.; Zeng, X.; Wang, Y. Design, synthesis and antibacterial activity of novel andrographolide derivatives. Bioorg. Med. Chem. 18, 4269–4274, 2010.

37. Sun, H.; Xu, L.; Yu, P.; Jiang, J.; Zhang, G.; Wang, Y. Synthesis and preliminary evaluation of neuroprotection of celastrol analogues in PC12 cells. Bioorg. Med. Chem. Lett. 20, 3844–3847, 2010.

38. Zhang, Z.; Li, S.; Jiang, J.; Yu, P.; Liang, J.; Wang, Y. Preventive effects of Flos puerariae lobatae water extract and its active ingredient puerarin in acute and chronic alcohol treated rat and mice model. Chinese Med. 5:36, 2010.

39. Xu, J.; Lu, Y.; Luo, H.; Huang, S.; Bao, J.; Cai, S.; Wang Y. Homology modeling of α-glucosidase and its interactions with andrograpolide derivatives. Lett. Drug Design Discov. 8, 440–451, 2011.

40. Chen, H.; Li, S.; Wu, J.; Jiang, J.; Wang, Y. Pharmacokinetic study of a novel stroke therapeutic, 2-[[(1,1-dimethylethyl)oxidoimino]methyl]-3,5,6-trimethylpyrazine, by a simple HPLC-UV method in rats. Eur. J. Drug. Metab. Ph. 36, 95–101, 2011.

41. Zeng, X.; Liu, X.; Liang, H.; Bian J.; Pei, G.; Dai, H.; Polyak, S. W.; Song, F.; Ma, L.; Wang, Y.; Zhang, Z. Synergistic effect of AL-1 and various antibiotics on the formation of biofilms and production ofexopolysaccharide and pyocyanin by Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 55, 3015–3017, 2011.

42. Cui, Q.; Zhang, G.; Yu, P.; Wang, Y. Synthesis and preliminary evaluation of anti-HIV agent AZT prodrug. Yao Xue Xue Bao. 46, 1015–1018, 2011.

43. Lu, X.; Wan, S.; Jiang, J.;  Jiang, X.; Yang, W.; Yu, P.; Xu, L.; Zhang, Z.; Zhang, G.; , Zaijun Z.; Shan, L.; Wang, Y. Synthesis and biological evaluations of novel apocynin analogues. Eur. J. Med. Chem. 46, 2691–2698. 2011.

44. Cui, Q.; Zhang, G.; Yu, P.; Wang, Y. Synthesis and preliminary evaluation of anti-HIV agent AZT prodrug.  Acta Pharmaceutica Sinica, 46, 1015–1018, 2011.

45. Yao, H.; Li, S.; Yu, P.; Tang, X.; Jiang, J.; Wang, Y. Reaction characteristics of andrographolide and its analogue AL-1with GSH as a simple chemical simulation of NF-κB Inhibition. Molecules 17, 728–739, 2011.

46. Sun, Y.; Yu.; Zhang, G.; Wang, L.; Zhong, H.; Zhai, Z.; Wang, L.; Wang, Y. Therapeutic effects of tetramethylpyrazine nitrone in rat ischemic stroke models. J. Neurosci. Res. 90, 1662–1669, 2012

47. Sun, Y.; Zhang, G.; Zhang, Z.; Yu, P.; Zhong, H.; Du, J.; Wang, Y. Novel multi-functional nitrones for treatment of ischemic stroke. Bioorg. Med. Chem. 20, 3939–3945, 2012.

48. Yu, P.; Xia, L.; Zhao, J.; Zhang, G.; Zhang, Z,; Lang, M.; Wang, Y. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs. Biol. Pharm. Bull. 35, 1295–1299, 2012.

49. Ma, Li.; Liu, X.; Liang, H.; Che, Y.; Dai, H.; Yu, K.; Liu, M.; Ma, L.; Yang, C-H.; Song, F.; Wang, Y.; Zhang, L. Molecular targets of 14-alpha-lipoyl andrographolide on quorum sensing in Pseudomonas aeruginosa.  Antimicrob. Agents Chemother. 56, 6088–6094, 2012.

50. Cui, G.; Hung, M.; Shan, L.; Lei, S.; Choi, I.; Zhang, Z.; Hoi, M. P.; Yu, P.; Wang, Y.; Lee, S. M. A novel danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways. Intl. J. Cardio. 168, 1349–1359, 2013.

51. Zhu, Y.; Yu, G.;  Zhang, Y.; Xu, Z.; Wang, Y.; Yan, G.;, He, Q. A novel andrographolide derivative AL-1 exerts its cytotoxicity on K562 cells through a ROS-dependent mechanism. Proteomics, 13,169–178, 2013.

52. Cui, Q.; Shan, L.; Zhu, H.;  Yu, P.; Wang, Y. Synthesis and preliminary evaluation of Danshensu derivatives modified at hydroxyl group. J. Intl. Pharm. Res. 40, 795–800, 2013.

53. Yan, G.; Zhou, H.; Wang, Y.; Zhong, Y.; Tan, Z.; Wang, Y.; He, Q. Protective effects of andrographolide analogue AL-1 on ROS-induced RIN-m β cell death by inducing ROS generation. PLoS One, 8(6):e63656, 2013.

54. Talantovaa, M.; Sanz-Blascoa, S.; Zhang. X.; Xia, P.; Waseem Akhtara, M.; Okamotoa, S.; Dziewczapolskib, G.; Nakamuraa, T.; Gang, C.; Pratta, A. E.; Kanga, Y-J.; Tua, S.; Molokanovaa, E.; McKerchera, S. R.; Hiresd, A. A.; Sasone, H.; Stoufferf, D. G.; Buczynskif, M. W.; Solomong, J.; Michaelc, S.; Powersg, E. T.; Kellyg, J. W.; Robertsj, A.; Tonga, G.; Fang-Newmeyera, T.; Parkera, J.; Hollanda, E. A.; Zhang, D.; Nakanishia, N.; Chen, H-S, V.; Woloskere, H.; Wang, Y.; Parsonsf, L. H.;  Ambasudhana,R.;   Masliahc, E.; Heinemannb, S. F.; Piña-Crespoa, J. C.; Lipton, S. A. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. PNAS, 110, 2518–2527, 2013.

55. Xu, D.; Duan, H.; Du, J.; Zhang, Z.; Cui, W.; Wang, L.; Sun, Y.; Lang, M.; Hoi, P. M.; Han, Y.; Wang, Y.; Lee, S. M. The novel tetramethylpyrazine bis-nitrone (TN-2) protects against MPTP/MPP+-induced neurotoxicity via inhibition of mitochondrial-dependent apoptosis. J. Neuroimmun. Pharmacol. 9, 245–258, 2014.

56. Xu, D.; Zhang, K.; Zhang, Z.; Sun, Y.; Guo, B.; Wang, Y.; Hoi, P. M.; Han, Y.; Lee, S. M. A novel tetramethylpyrazine bis-nitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-κB and the PKCα/PI3-K/Akt pathways. Neurochem. Int. 78:76-85, 2014.

57. Guo, B.; Xu, D.; Duan, H.; Du, J.; Zhang, Z.; Lee, S. M.; Wang, Y. Therapeutic effects of multifunctional tetramethylpyrazine nitrone on models of Parkinson’s disease in vitro and in vivo. Biol. Pharm. Bull.  37, 274–285, 2014

58. Cui, W.; Zhang, Z.; Hu, S.; Mak, S.; Xu, D.; Choi, C.; Wang, Y.; Tsim, K.; Lee, M.; Rong, J.; Han, Y. Sunitinib produces neuroprotective effect via inhibiting nitric oxide overproduction. CNS Neurosci. Ther. 20, 244–252, 2014.

59. Sun, Y.; Liao, K.; Li, S.; Zhang, Z.; Yu, P.; Wang, Y. Pharmacokinetic analysis of bis-nitrone tetramethylpyrazine (TN-2) in rats and its protein binding in vitro. Lett. Drug Design and Discov. 11, 770–777, 2014.

60. Wu, H.; Li, W.; Sun, Y.; Xu, L.; Yu, P.; Wang, Y.; Zhang, Z. Determination of AL-1 in rat plasma and tissues by high-performance liquid chromatography and tts application in AL-1 pharmacokinetic study. J. Pharm. Biomed. Sci., 4, 573–580, 2014.

61. Lang, M.; Yan, R.; Wang, Y.; Yu, P. A selective O- and N-acylation protocol for carbamyl chloride. Chin. J. Org. Chem. 34(6):1227, 2014.

62. Cui, Q.; Chen, Y.; Zhang, M.; Shan, L.; Sun, Y.; Yu, P.; Zhang, G.; Wang, D.; Zhao, Z.; Xu, Q.; Xu, B.; Wang, Y. Design, synthesis and preliminary cardioprotective effect evaluation of Danshensu derivatives. Chem. Biol. & Drug Des. 84, 282–291, 2014.

63. Xu, L.; Li, Y.; Wan, S.; Wang, Y.; Yu, P. Apocynin nitrone protects rats from LPS-mediated acute lung injury via inhibition of NADPH oxidase. Intl. Immunopharmacol. 20, 377–382, 2014.

64. Liang, Z.; Du, E.; Xu, L.; Sun, Y.; Zhang, G.; Yu, P.; Wang, Y. Synthesis and preliminary biologic activity evaluation of nitric oxide-releasing andrographolide analogues. Chem. Pharma. Bull. 62, 519–523, 2014.

65. Zhang, Z.; Lai, D.; Wang, L.; Pei, Y.; Zhu, L.; Guo, B.; Xu, L.; Sun, Y.; Xu, L.; Zhou, L.; Sun, Y.; Lee, S-M.; Wang, Y. Neuroprotective effects of the andrographolide analogue AL-1 in the MPP+/MPTP-induced Parkinson’s disease model in vitro and in mice. Pharmacol. Biochem. Be. 122, 191–202, 2014.

66. Zhao, Y.; Szeto, S. S. W.; Kong, R. P. W.; Law, C. H.; Li, G.; Quan, Q.; Zhang, Z.; Wang, Y.; Chu, I. K. Online two-dimensional porous graphitic carbon/reversed phase liquid chromatography platform applied to shotgun proteomics and glycoproteomics. Anal. Chem. 86(24):12172–9, 2014.

67. Sun, Y.; Tan, Z.; Liang, Z.; Wang, L.; Shan, L.; Yu, P.; Wang, Y. Synthesis and relationship of stability and biological activity of new DSS and TMP conjugates. MedChemComm. 6, 586–591, 2014.  

68. Fu, P.; Li, Z.; Wang, Y.; Yu, P. Wang, Y. Yu, P. Synthesis of 3-(5H-pyrazolyl)-cyclobutanone derivatives. Asia J. Chem. 27(7): 2545–2547, 2015.

69. Law, C. H.; Szeto, S. S. W.; Kong, R. P. W.; Zhang, Z.; Wang, Y.; Quan, Q.; Lee, S. M. Y. Chu, I. K. A versatile reversed phase-strong cation exchange-reversed phase (RP-SCX-RP) multidimentional liquid chromatography platfprm for qualitative and quantitative shotgun proteomics. Analyst 140(4):1237–52, 2015.

70. Lang, M.; Yao, H.; Fu, P.; Cai, W., Wang, Y.; Yu, P. An unexpected replacement of a methyl with an amino in the tetramethylpyrazine system.  Res. Chem. Intermed. 41: 5621–5626, 2015.

71. Zhang, Z.; Li, G.; Szeto, S. S.; Chong, C.; Quan, Q.; C.; Cui, W.; Guo, B.; Wang, Y.; Han, Y.; Siu, M.; Lee, S. M.; Chu, I. K. Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson's disease. Free Radic. Biol. Med. 84:331–43, 2015.

72. Li, Y.; Yan, H.; Zhang, Z.; Zhang, G.; Sun, Y.; Yu, P.; Wang, Y.; Xu, L. Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signaling pathway. Br. J. Pharmacol. 172(12):3151–8, 2015.

73. Cui, G.; Shan, L.; Guo, L.; Chu, I. K.; Li, G.; Quan, Q.; Zhao, Y.; Chong, C.; Zhang, Z.; Yu, P.; Hoi, P. M.; Wang, Y.; Lee, S. M. Y. Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy. Sci. Rep. 5:10353, 2015.

74. Li, S.; Shan, L.; Zhang, Z.; Li, W.; Liao, K.; Li, S.; Yu, P.; Wang, Y. Pharmacokinetic and metabolism studies of ADTM, a novel Danshensu derivative confers cardioprotection by HPLC-UV and LC-MS/MS.  J. Chromatogr. Sci. 53(6):872–8, 2015.

75. Chen, H.; Xu, D.; Tan, G.; Cai, W.; Zhang, G.; Cui, W.; Wang, J.; Long, C.; Sun, Y.; Yu, P.; Tsim, K.; Zhang, Z.; Han, Y.; Wang, Y. A Potent multifunctional neuroprotective derivative of tetramethylpyrazine.  J. Mol. Neurosci. 56(4):977–87, 2015.

76. Lee, R.; Shan, L.; Zhang, Z.; Wang, Y.; Yang, C.; Kwan, Y-W.; Lee, S. M.; Hoi, M. P.; Chan, S-W.; Cheung, A. C.; Cheung, K-H. Relaxation effect of a novel danshensu/tetramethylpyrazine derivative on rat mesenteric arteries. Eur. J. Pharmacol. 761:153–60, 2015.

77. Quan, Q.; Szeto, S. S. W.; Zhang, Z.; Wang, Y.; Chu, I. K. Fully automated multidimensional reversed-phase liquid chromatography with tandem anion/cation exchange columns for simultaneous global endogenous tyrosine nitration detection, integral membrane protein characterization, and quantitative proteomics mapping in cerebral infarcts. Anal. Chem. 87(19):10015–24, 2015.

78. Hu, S.; Cui, W.;  Zhang, Z.; Mak, S.; Xu, D.; Li, G.; Hu, Y.; Wang, Y.; Lee, M.; Tsim, K.W.; Han, Y. Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β. J. Mol. Neurosci. 57(4):561–570, 2015

79. Takahashi, H.; Xia, P.; Cui, J.; Talantova, Bodhinathan,K.; Li, W.; Holland, E.; Tong, G.; Pina-Crespo, J.; Zhang, D.; Nakanishi, N.; Larrick, J. W.; McKercher, S.; Nakamura, T.; Wang, Y.; Lipton, S.A. Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease. Sci. Rep. 5:14781, 2015.

80. Zhu, L.; Sun, Y.; Zhang, G.; Yu, P.; Wang, Y.; Zhang, Z. Radical-scavenging and anti-oxidative activities of TBN in cell-free system and murine H9c2 cardiomyoblast cells. J. Antioxid. Activity 1:1–55, 2015.

81. Zhou, X.; Zhu, L.; Wang, L.; Guo, B.; Zhang, G.; Sun, Y.; Zhang, Z.; Lee, M-Y.; Yu, P.; Wang, Y. Protective effect of edaravone in primary cerebellar granule neurons against iodoacetic acid-induced cell injury, Oxidat. Med. Cell. Longev. 2015:606981, 2015.

82. Yan, H.; Li, Y.; Yang, Y.; Zhang, Z.; Zhang, G.; Sun, Y.; Yu, P.; Wang, Y.; Xu, L. Protective effects of andrographolide derivative AL-1 on high glucose-induced oxidative stress in RIN-m cells. Curr. Pharm. Des. 22(4):499–505, 2016.   

83. Wang, L.; Zhang, X.; Chan, J.; Shan, L.; Cui, Q.; Wang, Y.; Li, J.; Chen, H.; Zhang, Q.; Yu, P.; Han, Y.; Wang, Y.; Lee, S-M. A novel danshensu derivative prevents cardiac dysfunction and improves the chemotherapeutic efficacy of doxorubicin in breast cancer cells" J. Cell. Biochem. 117, 94–105, 2016.

84. Li, X.; Liu, Z.; Wu, L.; Zhang, Z.; Wang, Y.; Sun, Y.; Yu, P. Synthesis and biological evaluation of tetramethylpyrazine nitrates as potential anti-ischemic agents. Asia. J. Chem., 28, 2085–2088, 2016.

85. Liu, W.; Lang, M.; Youdim, M.B.H.; Amit, T.; Sun, Y.; Zhang, Z.; Wang,Y.; Weinreb, O. Design, synthesis and evaluation of novel dual monoamine-cholinesterase inhibitors as potential treatment for Alzheimer's disease, Neuropharmacology 109:376–385, 2016.

86. Jiang, X.; Yang, J.; Zhang, F.; Yu, P.; Sun, Y,; Wang, Y. Facile synthesis of 3-halobenzo-heterocyclic-2-carbonyl compounds via in situ halogenation-oxidation. Adv. Synth. Catal. 358, 2678–2683, 2016.

87. Jiang, X.; Yang, J.; Zhang, F.; Yu, P.; Sun, Y,; Wang, Y. Synthesis of quaternary 3,3-disubstituted 2-oxindoles from 2-substituted indole using selectfluor. Org. Lett. 18, 3154–3157, 2016.

88. Zhao, H.; Osborne, O. J.; Lin, S.; Ji, Z.; Wang, Y.; Nel, A. E.; Lin, S. Lanthanide hydroxide nanoparticles induce angiogenesis via ROS-sensitive signaling.  Small 12(32):4404–11, 2016

89. Hu, S.; Wang, L.; Mak, S.; Zhang, Z.; Xu, D.; Li, H.; Li, Y.; Hu, Y.; Lee, S. M.; Wang, Y. Potent protection against MPP+-induced neurotoxicity via activating transcription factor MEF2D by a novel derivative of naturally occurring danshensu/tetramethylpyrazine. Neuromol. Med. 18(4):561–572, 2016.

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