单璐琛

博士/副研究员/硕士生导师

通讯地址:                     暨南大学药学院,广州市黄埔大道西601号,邮编:510632
E-mail:                            ytysxs@126.com

 

教育经历:                               
1998 - 2003         学士(临床药学),大连医科大学
2004 - 2009         博士(药理学),哈尔滨医科大学
  
工作经历:     
2009 - 至今         暨南大学药学院新药研究所,副研究员,硕士研究生导师
 
研究方向:         
心血管活性化合物的研究与开发
 
研究成果:
先后主持国家自然科学基金、广东省公益研究与能力建设专项基金、广东省卫生厅科研基金,广东省中医药局科研项目等 8 项,参与国家、省、市级课题多项。已发表论文 40 余篇,被 SCI 收录论文 27 篇。参与申请发明专利 3 项。参编人卫社《药理学》数字化教材 1 部(编委)。
 

 

发表的部分论文 (English)

 

1. Jiang J, Jian Q, Jing M, Zhang Z, Zhang G, Shan L, Yu P, Wang Y, Xu L. The novel N-methyld-aspartate receptor antagonist MN-08 ameliorates lipopolysacch-aride-induced acute lung injury in mice. Int Immunopharmacol. 2019Jan;66:109-118. 
2. Zhang Y, Deng H, Zhou H, Lu Y, Shan L, Lee SM, Cui G. A novel agent attenuates cardiotoxicity and improves antitumor activity of doxorubicin in breast cancer cells. J Cell Biochem. 2018 Oct 10. doi: 10.1002/jcb.27880.
3. Li N, Song X, Wu L, Zhang T, Zhao C, Yang X, Shan L, Yu P, Sun Y, Wang Y, Zhang G, Zhang Z. Miconazole stimulates post-ischemic neurogenesis and promotes functional restoration in rats. Neurosci Lett. 2018 Nov 20;687:94-98.
4. Chen H, Cao J, Zhu Z, Zhang G, Shan L, Yu P, Wang Y, Sun Y, Zhang Z. A novel tetramethylpyrazine derivative protects against glutamate-induced cytotoxicity through PGC1α/Nrf2 and PI3K/Akt signaling pathways. Front Neurosci. 2018 Aug 15;12:567. 
5. Hu S, Hu H, Mak S, Cui G, Lee M, Shan L, Wang Y, Lin H, Zhang Z, Han Y. A novel tetramethylpyrazine derivative prophylactically protects against glutamate-induced excitotoxicity in primary neurons through the blockage of N-methyl-D-aspartate receptor. Front Pharmacol. 2018 Feb 12;9:73.
6. Zhang G, Zhang T, Wu L, Zhou X, Gu J, Li C, Liu W, Long C, Yang X, Shan L, Xu L, Wang Y, Sun Y, Zhang Z. Neuroprotective effect and mechanism of action of tetramethylpyrazine nitrone for ischemic stroke therapy. Neuromolecular Med. 2018 Mar;20(1):97-111.
7. Tang F, Zhou X, Wang L, Shan L, Li C, Zhou H, Lee SM, Hoi MP. A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways. Eur J Pharmacol. 2018 Feb 5;820:86-96.
8. Zhang G, Zhang T, Li N, Wu L, Gu J, Li C, Zhao C, Liu W, Shan L, Yu P, Yang X, Tang Y, Yang GY, Wang Y, Sun Y, Zhang Z. Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post-ischaemic neuroregeneration and recovery of neurological functions in rats. Br J Pharmacol. 2018 Feb;175(3):517 -531. 
9. Xu B, Deng H, Zhang X, Luo J, Zhang G, Zhang Z, Wang Y, Shan L*. A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and  exerts cardioprotection in dogs. Eur J Pharmacol. 2018 Jan 5;818:158-166. (*corresponding author)
10. Zhang X, Luo J, Huang Y, Deng H, Hu H, Yu P, Sun Y, Shan L*, Wang Y. A novel DanshensuTetramethylpyrazine conjugate DT-018 provides cardioprotection by preserving mitochondrial function through the MEF2D/PGC-1α pathway. Curr Pharm Des. 2018 Feb 12;23(39):60626070. (*corresponding author)
11. Zhang X, Hu H, Luo J, Deng H, Yu P, Zhang Z, Zhang G, Shan L*, Wang Y. A Novel Danshensu Tetramethylpyrazine Conjugate DT-010 Provides Cardioprotection through the PGC1α/Nrf2/HO-1 Pathway. Biol Pharm Bull. 2017 Sep 1;40(9):1490- 1498. (*corresponding author)
12. Wang Y, Zhang X, Xu C, Zhang G, Zhang Z, Yu P, Shan L*, Sun Y, Wang Y. Synthesis and biological evaluation of Danshensu and Tetramethylpyrazine conjugates as cardioprotective agents. Chem Pharm Bull (Tokyo). 2017;65(4):381-388. (*corresponding author)
13. Cui G, Shan L, Chen Y, Zhou H, Wang Y, Lee SM. A new Danshensu derivative protects against 6-hydroxydopamine-induced neurotoxicity in vitro and In vivo. Am J Chin Med. 2016;44(7):1349-1361.
14. Wang L, Chan JY, Zhou X, Cui G, Yan Z, Wang L, Yan R, Di L, Wang Y, Hoi MP, Shan L*, Lee SM. A novel agent enhances the chemotherapeutic efficacy of doxorubicin in MCF-7 breast cancer cells. Front Pharmacol. 2016 Aug 10;7:249. (*corresponding author)
15. Yang Y, Yan H, Jing M, Zhang Z, Zhang G, Sun Y, Shan L, Yu P, Wang Y, Xu L. Andrographolide derivative AL-1 ameliorates TNBS-induced colitis in mice: involvement of NF-кB and PPAR-γ signaling pathways. Sci Rep. 2016 Jul 20;6:29716.
16. Wang L, Zhang X, Cui G, Chan JY, Wang L, Li C, Shan L, Xu C, Zhang Q, Wang Y, Di L, Lee SM. A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II. Oncotarget. 2016 May 31;7(22):32054-64.
17. Wang L, Zhang X, Chan JY, Shan L*, Cui G, Cui Q, Wang Y, Li J, Chen H, Zhang Q, Yu P, Han Y, Wang Y, Lee SM. A novel Danshensu derivative prevents cardiac dysfunction and improves the chemotherapeutic efficacy of doxorubicin in breast cancer cells. J Cell Biochem. 2016 Jan;117(1):94-105. (*corresponding author)
18. Cui G, Shan L*, Guo L, Chu IK, Li G, Quan Q, Zhao Y, Chong CM, Zhang Z, Yu P, Hoi MP, Sun Y, Wang Y, Lee SM. Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy. Sci Rep. 2015 Jun 3;5:10353. (*cofirst author)
19. Sun Y, Tan Z, Liang Z, Wang L, Shan L*, Yu P, Lee SM, Wang Y. Synthesis and relationship of stability and biological activity of new DSS and TMP conjugates. Med Chem Comm. 2015; 6:586-91. (*corresponding author)
20. Li RW, Yang C, Shan L, Zhang Z, Wang Y, Kwan YW, Lee SM, Hoi MP, Chan SW, Cheung AC, Cheung KH, Leung GP. Relaxation effect of a novel Danshensu/ tetramethylpyrazine derivative on rat mesenteric arteries. Eur J Pharmacol. 2015 Aug 15;761:153-60.
21.
Li S, Shan L*, Zhang Z, Li W, Liao K, Li S, Sheng X, Yu P, Wang Y. Pharmacokinetic and Metabolic Studies of ADTM: A novel Danshensu derivative confers cardioprotection by HPLCUV and LC-MS/MS. J Chromatogr Sci. 2015 Jul;53(6):872-8. (*corresponding author)
22. Cui Q, Chen Y, Zhang M, Shan L*, Sun Y, Yu P, Zhang G, Wang D, Zhao Z, Xu Q, Xu B, Wang Y. Design, synthesis, and preliminary cardioprotective effect evaluation of danshensu derivatives. Chem Biol Drug Des. 2014 Sep;84(3):282-91. (*corresponding author)
23. Cui G, Shan L*, Hung M, Lei S, Choi I, Zhang Z, Yu P, Hoi P, Wang Y, Lee SM. A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways. Int J Cardiol. 2013 Sep 30;168(2):1349-59. (*corresponding author)
24. Lu X, Wan S, Jiang J, Jiang X, Yang W, Yu P, Xu L, Zhang Z, Zhang G, Shan L,  Wang Y. Synthesis and biological evaluations of novel apocynin analogues. Eur J Med Chem. 2011 Jul;46(7):2691-8.
25. Cai B, Shan L, Gong D, Pan Z, Ai J, Xu C, Lu Y, Yang B. Homocysteine modulates sodium channel currents in human atrial myocytes. Toxicology. 2009 Feb 27;256(3):201-6. (*co-first author)
26. Pan Z, Feng T, Shan L, Cai B, Chu W, Niu H, Lu Y, Yang B. Scutellarin-induced endotheliumindependent relaxation in rat aorta. Phytother Res. 2008 Nov;22(11): 1428-33. 
27. Gong D, Zhang Y, Cai B, Meng Q, Jiang S, Li X, Shan L, Liu Y, Qiao G, Lu Y, Yang B. Characterization and comparison of Na+, K+ and Ca2+ currents between myocytes from human atrial right appendage and atrial septum. Cell Physiol Biochem. 2008;21(5-6):385-94. 

扫描二维码分享到微信